The fight to find effective, long-lasting treatments for cancer has led many researchers to consider protein degrading entities. Recent developments in PROteolysis TArgeting Chimeras (PROTACs) have signified their potential as possible cancer therapies. PROTACs are small molecule, protein degraders that function by hijacking the built-in Ubiquitin-Proteasome pathway. This review mainly focuses on the general design and functioning of PROTACs as well as current advancements in the development of PROTACs as anticancer therapies. Particular emphasis is given to PROTACs designed against various (...) types of Leukemia/Blood malignancies. (shrink)

Despite the economic relevance and distinctiveness of family firms, little attention has been devoted to researching their nature and functioning. Traditionally, family firms have been associated both to positive and negative features in their relationships with the stakeholders. This can be linked to different orientations toward corporate social responsibility. Thus, this research aims to identify the approaches that Spanish family firms maintain about social responsibility, based on the model developed by Quazi and O Brien Journal of Business Ethics 25, 33–51 (...) (2000). An empirical study carried out for 112 Spanish family firms gives support to our initial assumption about these organizations not being a homogeneous group in terms of their orientation towards corporate social responsibility. The differences in perceptions do not seem to be associated to biographical characteristics. These results lead to some relevant academic and practical implications that suggest interesting lines for future research. (shrink)

To survive and be successful in today's setting of globalisation and complexity, companies are obliged to think in wider strategic terms, developing active and enterprising strategies that include social, political and ecological elements, besides the economic ones. The analysis of the relationship between companies and society is especially interesting when these companies operate in international markets. Countries demand that large corporations contribute to local, regional and national development in such a way that their resources are exchanged for a significant increase (...) in their citizens' quality of life. Faced with that fact, the aim of this work is to establish what actions the subsidiaries will take in order to offer a response to the needs of their stakeholders in the host countries. Secondly, we attempt to identify the factors explaining the different levels of social response of the subsidiaries established in a particular country by different parent companies. The empirical study was carried out on a sample of Spanish subsidiaries in the two manufacturing industries with most foreign investment (the chemical and automobile industries) and the results obtained both confirmed the validity of the tool used to measure social response and permitted us to determine which factors influence the institutionalisation of social responsiveness. (shrink)

La perspectiva simult nea de filosof a y literatura, permite valorar qu grado de conocimiento hay en la ficci n, c mo se construyen subjetividad y texto, mundo y lenguaje. Muestra las posibilidades, te ricas y pr cticas, de la relaci n interna entre diferentes espacios argumentativos, entre actividades que poseen una vertiente creativa y, a la vez, una importante faceta reflexiva.

Banking firms are becoming increasingly aware that their clients’ management of environmental and social risks may in term threaten their own business as lenders and investors. In addition, stakeholders are requiring banks to improve their social performance. As a result, some banks are developing corporate social responsibility (CSR) policies and management systems to reduce potential risks and improve their performance. In the Spanish financial system, half of the banking firms are savings banks, most of which have always used some Corporate (...) Social Responsibility (CSR) criteria in their management. Private Banks have only recently started to integrate social aspects in their performance. However, no formal analysis has been carried out on the impact of CSR strategies. Various initiatives have been launched nationally and internationally to include the social dimension in management systems. The purpose of this research is to analyse the social performance of the main Spanish financial companies through public data such as social or sustainability reports and media sources. In order to do this, we need to determine which CSR criteria most greatly affect banking firms and to choose the most accurate quantitative and qualitative indicators to measure social performance. (shrink)

What new forms of ethical engagement are emerging in naturecultural worlds? In this paper I explore the example of the practical ethics of the permaculture movement. I put these in dialogue first with new approaches to ethics in biopolitics and naturecultures and second with a reading of feminist care ethics. Across this discussion I focus on the potential of ethos transformations experienced through everyday doings to promote ethical obligations of care. If we are living in a naturecultural world where politics (...) and ethics conflate in biopolitics, the permaculture movement is an example of an alter-biopolitical intervention. It works within bios with an ethics of collective empowerment that puts caring at the heart of its search of alternatives for hopeful flourishing for all beings. (shrink)

Art had always a prominent place in libertarian universe because the productions were advertising’s instruments that carried a marked ideological purpose. This article reconstructs the characteristics of anarchist art in Buenos Aires between 1900 and 1930. It studies the doctrinal texts of the main theorists and the way in which they influenced the local artists, as well as the articulation between local productions, newspaper articles and specialized art magazines, in order to address the aesthetic values that delineate these productions. It (...) concludes that, although anarchism preferred to exclude national realities due to its strong internationalism, argentine libertarian art had a strong local component that does not deny the libertarian anchorage of those artists and militants. (shrink)

To survive and be successful in today's setting of globalisation and complexity, companies are obliged to think in wider strategic terms, developing active and enterprising strategies that include social, political and ecological elements, besides the economic ones. The analysis of the relationship between companies and society is especially interesting when these companies operate in international markets. Countries demand that large corporations contribute to local, regional and national development in such a way that their resources are exchanged for a significant increase (...) in their citizens' quality of life. Faced with that fact, the aim of this work is to establish what actions the subsidiaries will take in order to offer a response to the needs of their stakeholders in the host countries. Secondly, we attempt to identify the factors explaining the different levels of social response of the subsidiaries established in a particular country by different parent companies. The empirical study was carried out on a sample of Spanish subsidiaries in the two manufacturing industries with most foreign investment (the chemical and automobile industries) and the results obtained both confirmed the validity of the tool used to measure social response and permitted us to determine which factors influence the institutionalisation of social responsiveness. (shrink)

El presente trabajo proporciona una perspectiva epistemológica al tratamiento dado por Cabriada a los alimentos. Las referencias a los alimentos en la _Carta Filosófica, Médico-Química_ (1687) son escasas pero relevantes. El examen crítico de los pasajes donde se mencionan determinados productos pone de manifiesto cuál es su interés epistémico para una medicina moderna. El lenguaje tradicional, que distinguía los «alimentos fríos y húmedos» de los «alimentos calientes y secos», deja paso al nuevo lenguaje físico-químico donde se habla de propiedades como (...) la acidez y la salinidad asociadas al movimiento de los átomos y a su configuración. Los cambios afectan también a los remedios, que serán de carácter químico y a base de plantas americanas como la quinaquina. Pese a este cambio, Cabriada no rechaza la medicina antigua en bloque. El incorpora a Hipócrates, que preludia la observación y la experimentación modernas, y rechaza el galenismo tardío (oscuro y confuso) por estar plagado de términos subjetivos. (shrink)

RESUMENLa Carta de Derechos Fundamentales de la Unión Europea contribuye a desarrollar la ciudadanía europea, basada en valores comunes, como la justicia y la dignidad. La Carta se refiere al consentimiento libre e informado en Medicina y Biología, prohibiendo la clonación reproductiva y las prácticas eugenesicas. El artículo considera el papel de los temas de Bioética en la expansión de los derechos de los ciudadanos; los debates recientes han demostrado que los derechos han de estar garantizados y, además, que las (...) buenas practicas profesionales sólo pueden desarrollarse dentro de buenas instituciones. El artículo analiza el papel de los principios de gobernanza (transparencia, eficiencia, participación, rendición de cuentas), así como la relación interna entre éstos y la integración de las políticas publicas: las cuestiones de Bioética ejemplifican el proceso de «europeanización».PALABRAS CLAVEBIOÉTICA, UNIÓN EUROPEA, GOBERNANZA, BUENAS PRACTICAS, EUROPEANIZACIÓNABSTRACTThe Charter of Fundamental Rights of the European Union contributes to develop European citizenship based on common values like justice and dignity. The Charter refers to free and informed consent in Medicine and Biology, and prohibits reproductive cloning and eugenic practices. This article considers the role of bioethical topics in the expansion of citizens’ rights; in fact, recent debates not only have proved that rights have to be guaranteed but that good professional practice could only develop within good institutions. The article also analyzes the role of the principles of governance (transparency, efficiency, participation, accountability), and the internal relationship between these principles and the integration of social policies; bioethical issues could exemplify the process of Europeanization.KEY WORDSBIOETHICS, EUROPEAN UNION, GOVERNANCE, GOOD PRACTICES, EUROPEANIZATION. (shrink)

En este artículo examino la noción de amor a Dios (amour envers Dieu) en Descartes, conectándola con los principios metafísicos de su sistema y con los objetivos a los que da respuesta, y mostrando sus beneficios para la vida de todo hombre. Los desacuerdos de Spinoza en esta materia no constituyen una discrepancia menor, sino que adquieren relevancia sistémica desde el momento en que el amor Dei está conectado con nociones centrales de su filosofía, como la idea de Dios y (...) sus atributos, la relación del hombre con la sustancia infinita, la actividad mental-corporal, el conocimiento como expresión del deseo, la función liberadora de los afectos y la fruición del amor a Dios. Esta noción constituye una plataforma privilegiada para examinar las peculiaridades de los sistemas de Descartes y Spinoza, y deja ver notables diferencias en sus respectivos proyectos de naturalización de la realidad. (shrink)

The political question in Descartes is an enormously complex issue. The historical circumstances surrounding his life, philosophical principles and the strict epistemological considerations that he defended intertwine in a sort of biological- theoretical-practical crossroads. Our work unravels the keys of Cartesian politics commonly perceived as shadowy.

The aim of this research was to delimit the predictive and mediational model of resilience between character strengths to predict flourishing, in a sample of undergraduate students. After signing their informed consent, 642 university students completed three validated scales. Using an ex post facto design, regression, structural modeling, and mediation analyses were carried out, in order to construct a multi-causal predictive model. Results indicated a consistent predictive direct effect of character strengths on resilience and flourishing and of resilience on flourishing. (...) As hypothesized, resilience also showed a mediating effect on the relationship between character strengths and flourishing. Additionally, results also revealed that the reactive and proactive factors of resilience were explained by different character strengths, reinforcing the idea that the two directions are complementary and necessary. Finally, several implications were established for the practice of positive psychology. (shrink)

The state of computing science and, particularly, software engineering and knowledge engineering is generally considered immature. The best starting point for achieving a mature engineering discipline is a solid scientific theory, and the primary reason behind the immaturity in these fields is precisely that computing science still has no such agreed upon underlying theory. As theories in other fields of science do, this paper formally establishes the fundamental elements and postulates making up a first attempt at a theory in this (...) field, considering the features and peculiarities of computing science. The fundamental elements of this approach are informons and holons, and it is a general and comprehensive theory of software engineering and knowledge engineering that related disciplines (e.g., information systems) can particularise and/or extend to take benefit from it (Lakatos’ concepts of core theory and protective belt theories). (shrink)

Las vanguardias artísticas nacieron insertas en un mundo de cambios para destronar un sistema de órdenes que estaban en decadencia. En los inicios del XX se experimentó la primera gran crisis del canon estético que hasta entonces definía el arte, los vanguardistas lo cuestionaron provocando la ruptura del discurso narrativo tradicional y lo reinventaron hasta convertirlo en uno de los pilares del mundo contemporáneo, abriendo una puerta desde lo imposible a lo posible. Como se verá en este artículo, debido a (...) su sentido crítico, la obra de Nietzsche fue capaz de anticipar las coordenadas generales de las vanguardias con los ejes de su pensamiento: el nihilismo, la dicotomía dionisiaca/apolínea y la voluntad de poder como conceptos clave para comprender su génesis, el proceso de acción artística y su sentido. Para ello se recorrerá su obra en sus distintas etapas, y se interrelacionarán con las vanguardias, especialmente con el dadaísmo y el surrealismo. (shrink)

El presente trabajo se propone analizar las formas de autogestión corporal, entendidas como producción de demarcaciones corporales y simbólicas, que sostienen las mujeres trabajadoras sexuales en relación a sus clientes, problematizando la noción de “venta del cuerpo” como argumento científico y político para justificar el gobierno del cuerpo de las mujeres. Es así que, a través de un enfoque etnográfico con reflexividad, que privilegia el discurso de las protagonistas, prestaremos especial atención a la creación de las nociones de herramienta de (...) trabajo, prestación de servicios sexuales y selección de los clientes como maneras precisas de regular las formas de involucramiento del yo y la intimidad en el intercambio de sexo por dinero. Esto implica echar luz sobre los procesos de aprendizaje sobre cómo lidiar cotidianamente con las relaciones del mundo de la prostitución, entendiendo que la autogestión corporal de demarcaciones, fronteras, familiaridades y jerarquías es parte constitutiva de las relaciones monetarias en el mundo contemporáneo. En este sentido, buscaremos hacer una contribución a la relación fructífera entre estudios del cuerpo y de las sexualidades y la sociología y antropología económicas. (shrink)

The political question in Descartes is an enormously complex issue. The historical circumstances surrounding his life, philosophical principles and the strict epistemological considerations that he defended intertwine in a sort of biological- theoretical-practical crossroads. Our work unravels the keys of Cartesian politics commonly perceived as shadowy.

We revisit the nonrelativistic problem of a bound, charged particle subject to the random zero-point radiation field, with the purpose of revealing the mechanism that takes it from the initially classical description to the final quantum-mechanical one. The combined effect of the zpf and the radiation reaction force results, after a characteristic time lapse, in the loss of the initial conditions and the concomitant irreversible transition of the dynamics to a stationary regime controlled by the field. In this regime, the (...) canonical variables x, p become expressed in terms of the dipolar response functions to a set of field modes. A proper ordering of the response coefficients leads to the matrix representation of quantum mechanics, as was proposed in the early days of the theory, and to the basic commutator x^,p^=iħ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\left[ {\hat{x}},{\hat{p}}\right] =i\hbar $$\end{document}. Further, the connection with the corresponding Fokker–Planck equation valid in the Markov approximation, allows one to obtain the radiative corrections of qed. These results reaffirm the essentially electrodynamic and stochastic nature of the quantum phenomenon, as proposed by stochastic electrodynamics. (shrink)

Despite the economic relevance and distinctiveness of family firms, little attention has been devoted to researching their nature and functioning. Traditionally, family firms have been associated both to positive and negative features in their relationships with the stakeholders. This can be linked to different orientations toward corporate social responsibility. Thus, this research aims to identify the approaches that Spanish family firms maintain about social responsibility, based on the model developed by Quazi and O' Brien Journal of Business Ethics 25, 33-51 (...) (2000). An empirical study carried out for 112 Spanish family firms gives support to our initial assumption about these organizations not being a homogeneous group in terms of their orientation towards corporate social responsibility. The differences in perceptions do not seem to be associated to biographical characteristics. These results lead to some relevant academic and practical implications that suggest interesting lines for future research. (shrink)

Aunque admito sin reservas -nos dice Spinoza en su TTP- que todas las cosas son determinadas por leyes universales de la naturaleza a existir y a obrar de una forma fija y determinada, afirmo, no obstante, que [...], para el uso de la vida,...

Carta al editor / Letter to the editor / Carta ao editorPara citar esta carta / To reference this letter / Para citar esta carta Casas ML. Una nueva profesión técnica. ¿Y por qué no?. Pers Bioet. 2020; 24: 220-221. DOI: https://doi.org/10.5294/pebi.2020.24.2.8Publicado: 27/11/2020.